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The Global Alliance for Genomics and Health (Global Alliance) is an international coalition, formed to enable the sharing of genomic and clinical data. Genomic information offers great potential to inform the understanding of disease, but in order to learn it is often necessary to combine information across diseases, organizations, methods, and even countries. The members of the Global Alliance for Genomics and Health are working together to create interoperable approaches to help unlock these potential advancements in medicine and science.