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Our goal is to address your problem and prevent further soreness and pain with specialized knowledge of massage techniques, muscles and bones to improve your

Find information for healthcare professionals about Rituxan® (rituximab), the only FDA-approved treatment proven to induce remission in patients with GPA and MPA. INDICATION STATEMENT - Rituxan® (rituximab), in combination with glucocorticoids, is indicated for the treatment of adult patients with Granulomatosis with Polyangiitis (GPA) (Wegener’s Granulomatosis) and Microscopic Polyangiitis (MPA) - Limitations of Use: Rituxan is not recommended for use in patients with severe, active infections BOXED WARNINGS and Additional Important Safety Information BOXED WARNINGS Infusion Reactions: Rituxan administration can result in serious, including fatal, infusion reactions. Deaths within 24 hours of Rituxan infusion have occurred. Approximately 80% of fatal infusion reactions occurred in association with the first infusion. Monitor patients closely. Discontinue Rituxan infusion for severe reactions and provide medical treatment for Grade 3 or 4 infusion reactions. Severe Mucocutaneous Reactions: Severe, including fatal, mucocutaneous reactions can occur in patients receiving Rituxan. Hepatitis B Virus (HBV) Reactivation: HBV reactivation can occur in patients treated with Rituxan, in some cases resulting in fulminant hepatitis, hepatic failure, and death. Screen all patients for HBV infection before treatment initiation, and monitor patients during and after treatment with Rituxan. Discontinue Rituxan and concomitant medications in the event of HBV reactivation. Progressive Multifocal Leukoencephalopathy (PML): PML, including fatal PML, can occur in patients receiving Rituxan. Warnings and Precautions Rituxan administration can also result in additional serious, including fatal, adverse reactions including: - Tumor lysis syndrome (TLS): Administer aggressive intravenous hydration, anti‑hyperuricemic agents, monitor renal function - Infections: Withhold Rituxan and institute appropriate anti-infective therapy - Cardiac arrhythmias and angina: Discontinue infusions in case of serious or life-threatening events - Bowel obstruction and perforation: Consider and evaluate for abdominal pain, vomiting, or related symptoms - Live virus vaccines: Do not administer live virus vaccines prior to or during Rituxan - Cytopenias: Monitor blood counts at regular intervals Granulomatosis With Polyangiitis (GPA) (Wegener’s Granulomatosis) and Microscopic Polyangiitis (MPA) - Use of concomitant immunosuppressants other than corticosteroids has not been studied in GPA or MPA patients exhibiting peripheral B-cell depletion following treatment with Rituxan. Observe patients with GPA and MPA closely for signs of infection if immunosuppressants other than corticosteroids are used concomitantly - The safety and efficacy of retreatment with Rituxan have not been established in patients with GPA and MPA - Common adverse reactions (≥15%) in the clinical study were infections, nausea, diarrhea, headache, muscle spasms, anemia, and peripheral edema. Other important adverse reactions include infusion reactions You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at (888) 835-2555. For additional safety information, please see the Rituxan full prescribing information, including BOXED WARNINGS.

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We all have had one at some point of time. A muscle spasm is a common occurrence, when you extend the body under conditions of dehydration and heat, beyond a stage. When undernourished and overworked, running low on energy and fluids, muscles get spasms (short painful contractions). Through this Buzzle article, I provide an overview of the symptoms, causes and treatment strategies to you to heal muscle spasms. Muscle Function Muscles, with their contractile behavior, are primarily accountable for body motions. In ordinary cases, these voluntary muscles start contracting, when the brain sends electrical signals. These motor neurons stimulate the activation of calcium ions, within the cells of a muscle and act as a catalyst. There are two types of proteins within the muscle cells- Myosin and Actin. The release of calcium ions leads to interaction with proteins, which leads to sliding past one another of proteins of these ions. Recapture of ions leads to unlinking again. Muscle Spasm Occasionally, people have an uneasy feeling of tightness in muscles of legs, neck, arms or their back. Sportspersons, athletes or the folks associated with strenuous tasks get cramps in their own muscles. Both these forms are referred to as muscle spasms. Normally it's characterized by an abrupt burst of unpleasant, painful sense. Every muscle in the body is susceptible to muscle spasm, although it's more common in calf muscles or muscles of the back or neck. Muscle will not loosen after sudden stiffening when the body witness's muscle spasm. When it occurs in legs, it's also known as 'Charley Horse'. Normally, these muscle cramps up the crop from the simple fatigue of muscles, after surprising heavy exercise when the muscle is just not habituated to weights that are additional. It can also occur during pregnancy. Yet, there are few instances when disorders or electrolyte imbalances in neuromuscular functions cause spasms. Also, it could be a complication of certain medicines. Spasms can be catalyzed by the sudden moves, especially a sudden, tweaking move. Stretching that is slow and slow will be a successful option in such scenarios. In conditions that are abnormal, unusual contraction action of muscle cells at any period can result in these spasms. There is specific mechanism between the brain and the spinal cord and motor neurons of the central nervous system to regulate contraction activity. Interruption of the system results in a spasm. Being over sensitive, motor neurons may go bizarre in their functioning. Excitement takes place as muscle sheath itself is quite sensitive, without appropriate contraction. Discharged Calcium ions may not get recaptured in time, resulting in protracted contraction of muscles. Possible reasons behind the interruption of brain mechanism include too stress on particular muscles, injured nerve pathways, stroke, trauma, multiple sclerosis, spinal cord injury. Occasionally, nerve damage can result in a long-term shortening of the muscle, into contracture.

Body spasms, whether they are random or recurring, can be a scary ordeal. The causes behind muscle and whole-body spasms range from very minor to quite serious, which can often cause us to dream up all sorts of “worst case scenarios” in our mind or to ignore signs that may suggest something serious is at work. For the sake of having an idea of what possible afflictions could be at work, we are going to talk about three causes behind muscle and body spasms. We will also describe any additional symptoms that may show up in each circumstance.